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December 23, 2020    London, UK

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Organobismuth Redox Manifolds: Versatile Tools for Synthesis

2020-10-26

The ability of bismuth to maneuver between oxidation states supports several distinct reaction manifolds. Recent advances in the design, synthesis, and application of organobismuth reagents and catalysts illustrate the potential of these redox manifolds as tools complementary to conventional transition-metal-based synthetic strategies.

Kinetic and Thermodynamic Control in Dynamic Covalent Synthesis

2020-10-30

In recent years, dynamic covalent chemistry (DCC) has seen the synthesis of increasingly complex cyclooligomers, polymers, and diverse compound libraries. The reversible formation of covalent bonds characteristic of DCC reactions favors thermodynamic product distributions for simple uni topic reactions; however, kinetic effects are increasingly influential in reactions of multitopic precursors. In this review, we explore the interplay between thermodynamic and kinetic considerations when planning a DCC synthesis.

Nanoparticle Phototherapy in the Era of Cancer Immunotherapy

2020-11-18

Phototherapy, including photodynamic therapy (PDT) and photothermal therapy (PTT), exploits light to activate photoreactions that kill cancer cells. Recent studies show that phototherapy can not only kill irradiated tumor cells but also elicit a tumor-specific immune response. This phenomenon breaks the limitations of conventional phototherapy and has reinvigorated phototherapy-related research in the era of cancer immunotherapy. Nanoparticles play essential roles in this new campaign by allowing the simultaneous delivery of photoreactive agents and immune modulators.

Towards Lignin-Derived Chemicals Using Atom-Efficient Catalytic Routes

2020-11-27

Lignin is a potential non-fossil resource of diverse functionalized phenolic units. The most important lignin-derived monomers are 4-alkylphenols, 4-hydroxybenzaldehydes, 4-hydroxybenzoic acids, and 4-hydroxycinnamic acids/esters. Efficient transformation of lignin and/or its monomers into valuable aromatics and their derivatives is crucial, not only for a sustainable lignocellulose biorefinery but also to reduce our dependence on fossil feedstocks. This review provides a concise account of the recent advances in lignocellulose fractionation/lignin depolymerization processes towards lignin-derived monomers.

Amide Bond Activation: The Power of Resonance

2020-12-01

The amide bond represents the most fundamental functional group in numerous areas of chemistry, such as organic synthesis, drug discovery, polymers, and biochemistry. Although typical amides are planar and the amide N–C(O) bond is notoriously difficult to break due to nN??low asteriskC=O resonance, over the past 5 years remarkable breakthroughs have been achieved in the activation of amides by complementary mechanisms that ultimately hinge on ground-state destabilization of the amide linkage. In this review, we present an overview of the main reactivity manifolds employed in the activation of amides by selective N–C(O) cleavage pathways along with their main applications in catalytic as well as stoichiometric synthesis

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