Title: Critical Evaluation of Neuro-protective Drugs in Ayurveda

Abstract:

Plant secondary metabolites include an array of bioactive constituents form both medicinal and food plants able to improve human health. The exposure to those phytochemicals, including phenylpropanoids, isoprenoids and alkaloids, through correct dietary habits, may promote health benefits, protecting against the chronic degenerative disorders mainly seen in Western industrialized countries, like cancer, cardiovascular and neurodegenerative diseases. During this review, I briefly cope with some plant foods and herbs of traditional medicines and diets that specialize in their neuroprotective active components. Because oxidative stress and neuro-inflammation resulting from neuroglial activation, at the amount of neurons, microglial cells and astrocytes, are key factors within the etiopathogenesis of both neurodegenerative and neurological diseases, emphasis are going to be placed on the antioxidant and antiinflammatory activity exerted by specific molecules present in food plants or in remedies prescribed by herbal medicines. Neuroprotection refers to the strategies and relative mechanisms able to defend the central nervous system (CNS) against neuronal injury due to both acute (e.g. stroke or trauma) and chronic neurodegenerative disorders (e.g. Alzheimer's disease, AD, and Parkinson's disease, PD). Among these strategies, herbal medicine may represent a valuable resource in prevention rather than in therapy of some CNS diseases, in association with a healthy lifestyle including correct dietary habits and moderate physical activity. As complementary and alternative therapy, herbal medicine, or simply phyto-therapy, refers to the medical use of plant organs (leaves, stems, roots, flowers, fruits and seeds) for their curative properties. Generally, herbal products contain complex mixtures of active components, including phenylpropanoids, isoprenoids and alkaloids, and it is often difficult to determine which components of the herbs has biological activity.

Biography:

Dr. Sunil Pal has completed his B.A.M.S Graduation at the age of 24 years from Rajiv Gandhi University of Health Sciences (Bangalore), India. He is now pursuing Post graduation in M.D. Kayachikitsa (Internal Medicine- Ayurveda) from Maharashtra University of Health Sciences (Nashik), India. He has over 9 International Publications with 2 Abstract as titled in souvenir in his Post graduation academics period. Recently he has been awarded with “Bharat Gaurav Puraskar 2021” and “Certificate of Excellence” for outstanding contribution in the field of “Ayurveda Physician”. Recently nominated as “Young Scientist” by VDGOOD Foundation, Coimbatore & Also nominated as “National Excellency Award” by KTK Foundation, New Delhi. He has won many prizes in Quizzes, Paper presentations, Poster presentations, Essay writings, Article writings etc. He is active member of N.Y.L.P. NGO, Mumbai, India also Supporting Member of AAPNA (Association of Ayurvedic Professionals of North America, USA). He is currently doing research trial on Gokshura (Tribulus terrestris) herbs in Stage-I Hypertension. He is determined to pursue Academia Research. He is enamored of teaching and Clinical Research. He has main interest in Blood disorders, Neurology Auto-immune disorders, Oncology, Nephrology in Ayurveda.

Title: Autism and ADHD: Similarities and Differences and Implications for Underlying Biology and Conceptualization of Neuropsychiatric Disorders

Abstract:

In recent years, there has been a move to diagnose both Autism Spectrum Disorder (ASD) and Attention Deficit Hyperactivity Disorder (ADHD) in the same individuals.   But is it an accurate approach? Does it reflect biology?  

As it turns out, on the basis of simple symptom categorization, there is a fair amount of overlap between these two conditions.  There is a 5-10% incidence of ADHD overall in children, and a 2-5% incidence of ASD. Based on DSM-5, around 50% diagnosable with ASD could also be diagnosed with ADHD, and around 15% of children diagnosable with ADHD could also be diagnosed with ASD.   Both disorders make kids appear less engaged. Inattentive behavior in ADHD may cause affected children to miss social cues, which can resemble mild ASD. ADHD kids have a higher rate of peer rejection, which can lead to them being more withdrawn, which may also resemble ASD. Children with both disorders may develop problems with empathy, as well as facial recognition.

Children with ASD and ADHD both have high rates of depression and anxiety. Impulsive behavior and executive planning issues are similarly common. Both include problems with pragmatic language and cognitive flexibility. Both are more often found in the presence of intellectual disability or more specific learning disabilities such as in language, reading or motor skills.  There are genetic factors common to both disorders showing that they are not as different as previously thought.

Brain scans also reflect similarities.  There is a larger total brain and white matter volume in a subset of patients with ASD, but this is not typically seen in ADHD, whereas in both disorders a smaller corpus callosum (a connection between the right and left hemispheres of the brain) has been found in some patients. In functional neuroimaging, the most consistent finding in both disorders is reduced activation of front and side brain regions (the frontal and parietal lobes).

Effective behavioral treatments for the two disorders also have some overlap: In ASD the major goal is usually to promote social skills development, whereas in ADHD the major goal is usually on managing executive tasks; but controlling impulsive behavior is often a therapeutic focus in both disorders. Many of the therapeutic techniques used in each disorder are similar. For example, the positive reinforcement of desired behaviors, achieving consistent quality sleep, engaging in regular exercise, and assembling appropriate educational support are important strategies for treating both disorders.

Medications are similar as well. As with behavioral treatment, medication management focuses on targeting specific symptom improvement. So whether your child has ASD or ADHD, if the goal is to improve attention, a medication that has been FDA-approved for attention (ADHD) may be helpful. Conversely, there are some medications that have been FDA-approved for impulsive behaviors such as aggression in ASD. Although less common, these medications may sometimes be useful for impulse control in severe ADHD.

As we discover more similarities and differences, it is likely that our whole conception of how we diagnose many neuropsychiatric disorders will change from behavioral symptomatology to underlying biology.

Biography:

Sarah Cheyette MD is a Board Certified pediatric neurologist who practices in the San Francisco Bay Area. She has written and spoken extensively on ADHD and autism including her three books on ADHD: ADHD and the Focused Mind, Winning with ADHD, and ADHD & Me.  She graduated from Princeton cum laude, then UCLA medical school, finishing with her residency at Cedars Sinai and the University of Washington.Sarah Cheyette MD is a Board Certified pediatric neurologist who practices in the San Francisco Bay Area.  She has written and spoken extensively on ADHD and autism including her three books on ADHD: ADHD and the Focused Mind, Winning with ADHD, and ADHD & Me.  She graduated from Princeton cum laude, then UCLA medical school, finishing with her residency at Cedars Sinai and the University of Washington.