Personalized medicine, precision medicine, or theranostics is a medical model that separates people into different groups with medical decisions, practices, interventions and/or products being tailored to the individual patient based on their predicted response or risk of disease. The terms personalized medicine; precision medicine, stratified medicine and P4 medicine are used interchangeably to describe this concept through some authors and organizations use these expressions separately to indicate particular nuances. While the tailoring of treatment to patients dates back at least to the time of Hippocrates, the term has risen in usage in recent years given the growth of new diagnostic and informatics approaches that provide an understanding of the molecular basis of disease, particularly genomics. This provides a clear evidence base on which to stratify (group) related patients
Advances in human genome research are opening the door to a new paradigm for practicing medicine that promises to transform healthcare. Personalized medicine, the use of marker-assisted diagnosis and targeted therapies derived from an individual's molecular profile, will impact the way drugs are developed and medicine is practiced. Knowledge of the molecular basis of disease will lead to novel target identification, toxic genomic markers to screen compounds and improved selection of clinical trial patients, which will fundamentally change the pharmaceutical industry. The traditional linear process of drug discovery and development will be replaced by an integrated and heuristic approach. In addition, patient care will be revolutionized through the use of novel molecular predisposition, screening, diagnostic, prognostic, pharmacogenomics and monitoring markers. Although numerous challenges will need to be met to make personalized medicine a reality, with time, this approach will replace the traditional trial-and-error practice of medicine.
This perspective addresses conceptual approaches that can be undertaken to develop and apply clinical decision support in electronic health record systems to achieve personalized medical care. In addition, to represent meaningful benefits to personalized decision-making, a comparison of current and future applications of clinical decision support to enable individualized medical treatment plans is presented. If clinical decision support tools are to impact outcomes in a clear and positive manner, their development and deployment must therefore consider the needs of the providers, including specific practice needs, information workflow, and practice environment.
The development of cost-effective technologies able to comprehensively assess DNA, RNA, protein, and metabolites in patient tumours has fuelled efforts to tailor medical care. Indeed validated molecular tests assessing tumour tissue or patient germ line DNA already drive therapeutic decision making. However, many theoretical and regulatory challenges must still be overcome before fully realizing the promise of personalized molecular medicine. The masses of data generated by high-throughput technologies are challenging to manage, visualize, and convert to the knowledge required to improve patient outcomes. Systems biology integrates engineering, physics, and mathematical approaches with biologic and medical insights in an iterative process to visualize the interconnected events within a cell that determine how inputs from the environment and the network rewiring that occurs due to the genomic aberrations acquired by patient tumours determines cellular behaviour and patient outcomes. A cross-disciplinary systems biology effort will be necessary to convert the information contained in multidimensional data sets into useful biomarkers that can classify patient tumours by prognosis and response to therapeutic modalities and to identify the drivers of tumour behaviour that are optimal targets for therapy. An understanding of the effects of targeted therapeutics on signalling networks and homeostatic regulatory loops will be necessary to prevent inadvertent effects as well as to develop rational combinatorial.
Preventive Medicine is sharpened by all specialists to keep their patients sound. It is also an extraordinary therapeutic distinguishing strength saw by the American Board of Medical Specialties (ABMS). Preventive Medicine focuses on the prosperity of individuals, gatherings, and portrayed peoples. It is similarly used for the treatment for strength, visual hindrance. The Epidemiology Division applies inquire about systems to illustrations and explanations behind prosperity and affliction in the people and to make a translation of this learning into ventures proposed to turn away disease. The division has a long history of consideration in NIH-bolstered multi-site, longitudinal accomplice studies, and its staff deal with various pro began, NIH-upheld investigation endeavours and trials. Open trust in antibodies is a key to the accomplishment of immunization ventures worldwide in the time of preventive solution. The focus of Preventive Medicine and Public Health is health of individuals, communities, and defined populations. To, maintain health and protect, promote and to prevent disease, death and disability. The result of Public health surveillance is the identification and prioritization of public health issues the world is facing today, including HIV/AIDS, antibiotic resistance, diabetes, zoonotic diseases, and waterborne diseases. Preventive Medicine and Public health incorporates the interdisciplinary approaches of epidemiology, biostatistics and health services.
Precision Medicine in Oncology is doled out to illuminating, instructing, and encouraging the trading of clinically pertinent data with respect to the disclosure and utilization of new Drug regimens, Molecular biomarkers, Cancer genomics, Molecular growth and Diagnostics in strong tumors and hematologic malignancies, and in addition their effect on oncology watch over patients. Over late decades Cancer investigate has found an incredible and personalized medication to tumor research and treatment. The goal of the Personalized Medicine in cardiac research is to stimulate understanding of promising new essential examination disclosures for the treatment of heart disillusionment and arrhythmias through especially formed clinical trials that display suitability and security. Vascular Medicine encompasses an extensive variety of various sickness states. As the field of vascular Medicine builds up, the degree of ailments being managed changes. Cardiovascular revamping suggests the changes in estimate, shape, structure and physiology of the heart after harm to the myocardium. The mischief is regularly a direct result of extraordinary myocardial dead tissue. To depict the development in lipoprotein translation by hypothyroidism, adipocytes were prepared from control and hypothyroid rats. While LPL mix was higher in hypothyroid adipocytes, with no modification in mRNA levels, there was no extension in hormone-delicate lipase (HSL) mix.
The proteome is the entire set of proteins it is expressed by genome, cell, tissue, or organism at a certain time. More specifically, it is a combined of proteins and genomes. Proteomics is the study of the proteome. A cellular proteome is the collection of proteins present in a particular cell type and it exposure to hormone stimulation. It can also be useful to consider an organisms complete proteome, which can be conceptualized as the complete set of proteins from all of the various cellular proteomes. Proteome used to refer to the collection of proteins in certain sub-cellular biological systems.
A neurological issue is any tumor of the body sensory system. Auxiliary, biochemical or electrical variations from the norm of mind, spinal string or different nerves can bring about a scope of side effects. The indications incorporate loss of motion, muscle shortcoming, loss of sensation, seizures perplexity torment and changed levels of consciousness. They might be surveyed by neurological examination, considered and treated inside the specialties’ of neurology and clinical neuropsychology.
The procedures of globalization are making new threats to health care and its determinants. Medical problems that rise above national limits incorporate natural corruption and environmental change, disparity and way of life style changes, access to medicines and public health knowledge also additionally new and re-emerging diseases. We encourage participants from technological, community, clinical groups and individual perspectives. We inspire authors to arrange their papers with in global congress significant to their theme; to scrutinize business as usual and innovate new possibilities for public health globally. We plan to reflect and shape the thinking and enhance the health related decisions of scientists, experts, governments, and common society, corporates and United Nations agencies. The objective is to investigate enriching the human services through an interdisciplinary approach. It reflects our belief that in order to facilitate affordable & accessible healthcare delivery, one have to stay with developments in other disciplines in this very well developed & knowledgeable world. Public Health Congress 2017 is therefore a stage towards forging new dialogues with various stakeholders of Public health community beyond in Asian, European and USA Countries, acquiring new experiences and points of view from different fields, offering a stage on which to cultivate scholarly research among all partners and above all being the instrument of worldwide advances in health care.