Evidence in mice that bacteria in tumors help cancer cells metastasize

2022-04-14 - 2022-04

Bacteria promote cancer metastasis by bolstering the strength of host cells against mechanical stress in the bloodstream, promoting cell survival during tumor progression, researchers report April 7th in the journal Cell. "Our study reveals that the cancer cell's behavior is also controlled by the microbes hiding inside tumors, the majority of which were originally thought to be sterile," says senior author Shang Cai of the Westlake Laboratory of Life Sciences and Biomedicine. "This microbial involvement is distinct from the genetic, epigenetic, and metabolic components that most cancer drugs target." "However, our study does not mean that using antibiotics during cancer treatment will benefit patients," he says. "Therefore, it is still an important scientific question of how to manage the intratumor bacteria to improve cancer treatment in the future."

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Evidence in mice that bacteria in tumors help cancer cells metastasize

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Evidence in mice that bacteria in tumors help cancer cells metastasize