Title: Is Metformin the Answer for Distressed Females with Menstrual Irregularities?

Abstract:

This literature review is aimed to determine if metformin alone improves menstrual irregularities in females with the polycystic ovarian syndrome. The current literature review involves females with polycystic ovarian syndrome experiencing menstrual irregularity. The data was collected in PubMed and inclusion criteria included articles published in the past 10 years, articles involving only humans, articles written in the English language and considering women age 19 or more. The number of discovered articles was 1550 after the first search and only 25 articles that met the inclusion criteria were selected after quality assessment. The selected 25 articles that met the inclusion criteria after a review showed evidence for regulating menstrual cycles with metformin therapy alone among females with the polycystic ovarian syndrome. When metformin was used in addition to other pharmacologic agents, there was a more significant restoration of menstrual cycles. Monotherapy with metformin is found to be highly effective in treating menstrual irregularities experienced among patients with the polycystic ovarian syndrome. Greater improvement was noted with the addition of another agent to metformin. 

Biography:

Chavi Tejpal has completed her MD degree from Windsor University School of Medicine in St. Kitts & Nevis.

Title: Clinical Applications and Benefits of Using Closed-incision Negative Pressure Therapy with Novel Dressing: A Review Article

Abstract:

Surgical site occurrences (SSOs) are common in patients undergoing operative procedures, especially in the form of surgical site infections (SSIs). Multiple studies show that obesity, tobacco use, prolonged surgical time, and diabetes mellitus are the major risk factors for SSIs. SSIs increase healthcare costs and often result in morbidity. Many surgeons are currently using closed-incision negative pressure therapy (ciNPT) to counter SSIs. This method makes it easier for them to manage closed and surgical incisions. This technique has already been applied in the plastic surgery field. This study discusses how the use of ciNPT is helping surgeons to reduce complications related to SSOs. The technique has been reported to minimize the rate of reoperations, readmissions, and other wound-related complications. Using ciNPT with novel dressing has proved to be a significantly effective clinical intervention method in managing clean and closed wounds. The novel dressing protects the incision from external contamination and minimizes lateral tension. This study proves that the use of ciNPT is effective in reducing complications related to SSIs. The method minimizes the rate of reoperations, readmission, and other wound-related complications. Using ciNPT with novel dressing has proved to be a significant clinical and operative intervention method in managing clean and closed wounds. SSIs increase healthcare costs and often results in morbidity. The novel dressing protects the incision from external contamination and minimizes lateral tension. It also helps to normalize stress distribution, decrease lateral pressure on the incision, and increase appositional strength. We recommend that surgeons consider using ciNPT more frequently on patients undergoing procedures with a potential for high morbidity rate due to SSIs.

Biography:

Dennis Adjepong, MD. MBA is a surgeon intern at Alexandria Surgery Associates in Alexandria, VA. He graduated from Poznan University of Medical Science, Poland. His thirst for research is in the field of Neurosurgery/Neuroscience. Dennis received his Master’s in Business Administration from Strayer University, Washington DC. He is a member of the International. Behavioral Neuroscience Society (IBNS) and American Association for the Advancement of Science (AAAS). He is a published author with 15+ publications. He is an Editorial Board Member for Herald Scholarly Open Access Journal of Surgery: Current Trends & Innovations in Washington DC. Lastly, he has strong background in Computer science and Computer Network Security.

Title: Is There an Association Between Migraine and Major Depressive Disorder? A Narrative Review

Abstract:

Various studies on the association of migraine with depression are published. The comorbidity may upgrade health conditions up to a critical degree. Besides, the duration of symptoms and treatment may be prolonged. Moreover, these conditions can force substantial financial and social hardships on patients and their families. In this literature review, we intend to examine the evidence obtained on the possible associations between migraine and major depressive disorder (MDD). This review is focused on aminergic neurons. One of the variables associated with patients who experience both of these two diseases might have a history of assault. In migraine and MDD patients, genetic evidence, such as single nucleotide polymorphisms (SNP), was found to be one of the associations. Another theory concluded that actual headache diagnosed in patients who received no treatment manifests a history of anxiety, and later, the patients display severe somatic symptoms. In conclusion, there is a robust molecular genetic background, explaining the relationship between migraines and MDD. This correlated data renders a combination of both diagnoses as single separate entities. However, further studies are encouraged to point out the issue of treatment strategies. There is a robust molecular genetic background explaining the relationship between migraine and MDD. This correlated data renders a combination of both diagnoses as a single separate entity. However, further studies are encouraged to point out the issue of treatment strategies.

Biography:

Dennis Adjepong, MD. MBA is a surgeon intern at Alexandria Surgery Associates in Alexandria, VA. He graduated from Poznan University of Medical Science, Poland. His thirst for research is in the field of Neurosurgery/ Neuroscience. Dennis received his Master’s in Business Administration from Strayer University, Washington DC. He is a member of the International. Behavioral Neuroscience Society (IBNS) and American Association for the Advancement of Science (AAAS). He is a published author with 15+ publications. He is an Editorial Board Member for Herald Scholarly Open Access Journal of Surgery: Current Trends & Innovations in Washington DC. Lastly, he has strong background in Computer science and Computer Network Security.

Title: Wunderlich syndrome – a rare cause of hypovolemic shock – Case Report

Abstract:

Retroperitoneal  haemorrhage (Wunderlich  syndrome) is a  rare cause of hypovolemic shock in emergency patients;  however,  it is  associated  with a high morbidity and presents  a diagnostic  challenge in the Emergency Department. It is  more common  in female patients  older  than  50  years, and one of the leading causes is a benign renal  tumour angiomyolipoma (AML). Angiomyolipoma predominantly affects only one kidney. Bilateral  AML is  strongly associated  with a rare autoimmune disorder-tuberous sclerosis  and occur  in  80%  of  cases  of  TS.  Symptoms  caused  by  growing  renal  AML  are  absent  to  mild  and  non-specific  (intermittent  loin,  lower  back pains, haematuria). Rupture with  retroperitoneal  bleeding is a frequent complication  of AML and occurs  in 20%  of all  cases. Initial presentation of retroperitoneal haemorrhage is remarkably similar to a ruptured abdominal aortic aneurysm (AAA). Most  of the cases remain  clinically silent  during the growth  phase and present to the hospital  with  a  complication  in the form of retroperitoneal  bleeding. Risk of bleeding  increases with  the size  of the tumor and AML bigger than  4cm are treated with  selective embolization if  found on routine scanning. Many cases  of  AML are diagnosed  when  a patient  is  being scanned  for  other  medical problems. Even in an emergency when AML ruptures  is still  possible to treat it either  with selective embolization or  selective nephrectomy, and the majority of patients are making a successful recovery. Keywords:  Wunderlich  Syndrome (Retroperitoneal Haemorrhage); Renal Angiomyolipoma  (AML); Loin Pain  with  Haematuria; Hypovolemic Shock; Selective Embolization.

Biography:

Jaroslaw Nowacki currently works in Urgent Care Centre, Queen Mary’s Hospital Sidcup, Hurley Medical Group

Title: MR-Guided Radiation Therapy:Clinical Applications &Experiences

Abstract:

Magnetic Resonance (guided) Radiotherapy (MRgRT) is considered a suitable and versatile imaging modality that enhances direct visualization for tumors that surround the wounds among other organs at risk. MRgRT has marked the beginning of a new era, with its ability to provide real-time imaging that tracks and characterizes each anatomical motion. Initially, the technology was challenging,with the next-generation hybrid MR systems still having limited applicability to clinical practice. Adaptive radiotherapy is also an adequate procedure, given the monitoring variations targeting the neighboring structures to enhance uniformity of the treatment procedures. This is sufficient since a single plan may be inaccurate in exploring the wound’s exposure. MRI is also adequate as it provides soft tissue superior in image contrasts as compared to the standard X-ray technologies without exposure to radiation. Lastly, pre-operative MRgRT has shown delineation given the less inner-observer variations as compared to postoperative procedures.MRI has proved very sensitive to the detection of findings. Patients also receive earlier detection and treatment for successful clinical outcomes. The robust use of MRgRT improvement and safety applications in artificial intelligence have enhanced improved quality of contours, also reducing uncertainties and improving the overall quality of imaging.Other involved healthcare complications, including Glioblastoma and other ulcers, require unique therapeutic strategies changing the way clients receive their treatment. The past decade has also proven to have deficient tumor control, high survival rates, and reduced toxicity occurrences. More accurate imaging tools and gating solutions have been useful in achieving higher authentic images, hence the effective treatment of tumors in the overall.

Biography:

Dennis Adjepong, MD. MBA is a surgeon intern at Alexandria Surgery Associates in Alexandria, VA. He graduated from Poznan University of Medical Science, Poland. His thirst for research is in the field of Neurosurgery/ Neuroscience. Dennis received his Master’s in Business Administration from Strayer University, Washington DC. He is a member of the International. Behavioral Neuroscience Society (IBNS) and American Association for the Advancement of Science (AAAS). He is a published author with 15+ publications. He is an Editorial Board Member for Herald Scholarly Open Access Journal of Surgery: Current Trends & Innovations in Washington DC. Lastly, he has strong background in Computer science and Computer Network Security.

Title: Radiation Therapy as a Modality to Create Abscopal Effects: Current and Future Practices

Abstract:

In our empathetic understanding of abscopal effect (AbE), research has shown that the immune system is stimulated by radiation, which results in the formation of an AbE. The AbE is referred to as a response from the irradiated volume. Despite the existence of key gaps in our understanding, there is an urgent need to explore what the underlying effect is. The aim of this article is to argue neurosurgeons and the healthcare practitioner's knowledge of the AbE. Our goal is to identify more gaps in our understanding of the AbE and seal other gaps as well. This study will review medical journals and bring together the most updated information related to AbEs. The study explores diverse criteria depicting regression in lesions located off the irradiation field. The identification of AbE after radiation also has distinct treatment options and effects of immunotherapy. Notably, healthcare practitioners and surgeons are concerned with the patient's health, believing that RT as a modality in creating AbEs helps improve patient health and outcomes. The process guarantees a more precise identification of AbE inductions. Further studies are also expected to improve the sequencing of RIT with RT as a modality in creating AbEs to enact appropriate approaches during the diagnosis and treatment processes to achieve optimal immunogenic responses.

Biography:

Dennis Adjepong, MD. MBA is a surgeon intern at Alexandria Surgery Associates in Alexandria, VA. He graduated from Poznan University of Medical Science, Poland. His thirst for research is in the field of Neurosurgery/ Neuroscience. Dennis received his Master’s in Business Administration from Strayer University, Washington DC. He is a member of the International. Behavioral Neuroscience Society (IBNS) and American Association for the Advancement of Science (AAAS). He is a published author with 15+ publications. He is an Editorial Board Member for Herald Scholarly Open Access Journal of Surgery: Current Trends & Innovations in Washington DC. Lastly, he has strong background in Computer science and Computer Network Security.