Title: p53 Immunohistochemistry Is a Reliable Method for Assessing TP53 Allelic and Functional Status in TP53 Mutated Cases

Abstract:

TP53 alterations play an important role in the development, classification, and prognostication of myeloid neoplasms. Earlierstudies of myelodysplastic neoplasms (MDS) have shown that biallelic TP53 alterations, rather than monoallelic mutations,are associated with complex karyotypes and poor outcomes [1].These observations are consistent with the primary role of TP53as a tumor suppressor gene, which often requires loss of hetero-zygosity (LOH) for complete functional inactivation. Currently,establishment of biallelic TP53 alteration status is based on: (1)a TP53 mutation + TP53 copy loss or copy- neutral LOH; or (2)more than one TP53 mutation; or (3) one TP53 mutation with a variant allele frequency (VAF) of ≥ 50%

Biography:

C Cameron Yin has received her MD from Beijing Medical University and her PhD from the University of Wisconsin-Madison. She is currently an Associate Professor in the Department of Hematopathology at the University of Texas MD Anderson Cancer Center. In addition to clinical responsibilities on the Leukemia, Lymphoma and Molecular Diagnostic services, she has been actively participating in multiple research projects in the molecular genetic abnormalities in leukemia and lymphoma which has led to over 100 research papers and over 20 book chapters.