EpigeneticsEpigenetics is the study of heritable changes in gene expression (active versus inactive genes) that do not involve changes to the underlying DNA sequence a change in phenotype without a change in genotype which in turn affects how cells read the genes.
Clinical epigenetics Clinical epigenetics is the application of molecular biology techniques detecting alterations in DNA methylation or histone modification to diagnose or study disorders characterized by heritable defects in the expression of a gene or genome
Animal EpigeneticsBreakthroughs in genomic technologies have rapidly increased scientific understanding of the fundamental role that host and pathogen genetics play in how infections spread, and how they further affect the productivity of livestock systems and food supply chains.
Cancer EpigeneticsCancer epigenetics is the study of epigenetic modifications to the genome of cancer cells that do not involve a change in the nucleotide sequence.
Computational EpigeneticsResearch in computational epigenetics comprises the development and application of bioinformatics methods for solving epigenetic questions, as well as computational data analysis and theoretical modeling in the context.
Current Case studies Discussions EpigeneticsThe increased knowledge of epigenetics, combined with rise of technologies such as CRISPR/Cas9 gene editing and next-generation sequencing in recent years, allows us to better understand the interplay between epigenetic change, gene regulation, and human diseases, and will lead to the development of new approaches for molecular diagnosis and targeted treatments across the clinical spectrum.
Developmental EpigeneticsRobin Holliday defined epigenetics as "the study of the mechanisms of temporal and spatial control of gene activity during the development of complex organisms." Thus epigenetic can be used to describe anything other than DNA sequence that influences the development of an organism.
Epigenetic Diseases Clinical ApplicationsClinical epigenetics is the application of molecular biology techniques detecting alterations in DNA methylation or histone modification to diagnose or study disorders characterized by heritable defects in the expression of a gene or genome
Epigenetic RegulationEpigenetics is an emerging frontier of science that involves the study of changes in the regulation of gene activity and expression that are not dependent on gene sequence.
Epigenetics AlterationA heritable change that does not affect the DNA sequence but results in a change in gene expression. Examples include promoter methylation and histone modifications.
Epigenetics and Environmental Origins of CancerEnvironmental contaminants and toxicants are widespread throughout the world, and can include various materials and chemicals, from byproducts of combustion to contaminating trace metals and residual organic compounds used in daily life.
Epigenetics Biomarkersepigenome refers to the complete description of all potentially heritable modifications of the genome without any changes in primary DNA sequences. Therefore, epigenetic biomarkers can be broadly defined as measurable modifications of the genome with preserved DNA sequence.
Epigenetics FactorsEpigenetics is the study of heritable changes in gene expression (active versus inactive genes) that do not involve changes to the underlying DNA sequence — a change in phenotype without a change in genotype — which in turn affects how cells read the genes.
Epigenetics MechanismEpigenetics is defined as heritable changes in gene activity and expression that occur without alteration in DNA sequence
Developmental EpigeneticsRobin Holliday defined epigenetics as "the study of the mechanisms of temporal and spatial control of gene activity during the development of complex organisms." Thus epigenetic can be used to describe anything other than DNA sequence that influences the development of an organism.