Title: Carbon dots assisted laser desorption/ionization mass spectrometry for sensing of small-molecules

Abstract:

Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) may be a rapid analytical tool for the sensing of small molecules. In MALDI- TOF MS, the matrix plays key functions and acts as energy mediator for absorbing and transferring the laser energy to analytes for effective ionization and desorption. α-Cyano-4-hydroxycinnamic acid (CHCA), sinapic acid (SA) and a pair of,5-dihydroxy carboxylic acid (DHB) are commonly used matrices. However, MALDI-TOF MS is difficult to research small mass compounds (less than 500 M.Wt) because of generating sizable amount of fragment or clustering signals from the organic matrices, which severely interfering the analyte peaks. Additionally, non-homogeneous co-crystallization of matrix with sample and sweet spot effect are major drawbacks resulting in poor reproducibility. Nanoparticles assisted laser desorption/ionization (NALDI-TOF MS) mass spectrometry has been intensively used. Many nano materials are used including CDs, CdSe, Pt, HgTe, ZnO, etc. Various quite carbon-based materials like graphene and graphene oxide and nanotube have exhibited their capacity as a perfect matrix for the detection of important analytes using MALDI-TOF-MS. Among of these nano materials matrices, CDs gained significate attention thanks to their unique physical and chemical properties. Several instances where the flexibility of the C-dots are proved as an efficient matrix for the detection and quantification of biological analytes. Here, we discussed about synthesis, properties and role of CDs in

Biography:

Dr. Gangaraju Gedda currently is an Associate Professor in Vishnu Institute of Technology, India (2020-till now). He received his MS degree in JNT University, India in 2009 and Ph.D. degree from the National Sun Yat Sen University, Taiwan in 2015. Followed by Postdoctoral appointments at National Taiwan University of Science and Technology, Taiwan. He went back to India and worked as an Assistant Professor in GITAM University (2017–2020). He also serves as the reviewer in more than 5 journals and also serves as a resource person in several nitration conferences in India, Taiwan and USA. To date, he has 25 publications with 661 citation and h- index-15, and 2 book chapters.