Title: The newly identified proteins involved in the chromosome segregation in Mycobacteria- the functional analysis

Abstract:

Chromosome segregation in bacteria is an active process involving a number of proteins. In most of the bacteria, it depends on the presence of ParABS system. ParB segregation protein binds to the parS sequence and forms segregation complexes. ParA segregation protein interacts with ParB complexes being responsible for their distribution
ParA homologs: C. cresentus MipZ, C. glutamicum PldP, MipZ exhibited nonspecific DNA binding activity similar to ParA-like proteins.
Characteristic Features of Mycobacteria: Rod shaped, Slow growing, Gram positive bacteria with high ( G + C ) content (61 - 71% ), Lipid rich cell wall, Resistant to many environmental factors: drying, high and low temperature, high and low pH
Unique chromosome organisation and segregation in Mycobacteria: Chromosome is positioned asymmetrically in M. smegmatis cells. oriC is in the off-centre position after oriC duplication, new pole segrosome migrates faster than old pole segrosome mycobacterial cell elongate asymmetrically – the old pole extends faster
ParA in M. smegmatis
ParA is responsible for the localisation of the ParB complexes in the cell
● parA deletion strain is characterized by slow growth ● parA deletion results in formation 30% of anucleate cells

Biography:

Rudra Suresh is a Medical biotechnology engineering graduate with a record of outstanding research skills, comprehensive knowledge of food standards regulations and operational dexterity in fast-paced laboratory environment. She is looking for a position in which I can make the best use of my scientific background and my creativity in order to develop innovative products, and solutions. She is interested in all aspects of the biotechnology industry from R&D to QC. She really would like to find a role in which she can constantly learn new skills and increase her knowledge.