How poor oral hygiene may result in metabolic syndrome

2021-03-19 - 2021-03

Periodontal or gum disease is known to be a significant risk factor of metabolic syndrome, a group of conditions increasing the risk for heart disease and diabetes. In a new study, researchers from Tokyo Medical and Dental University (TMDU) discovered that infection with Porphyromonas gingivalis, the bacterium causing periodontal disease, causes skeletal muscle metabolic dysfunction, the precursor to metabolic syndrome, by altering the composition of the gut microbiome. Periodontal bacteria have long been known to cause inflammation within the oral cavity, but also systemically increase inflammatory mediators. As a result, sustained infection with periodontal bacteria can lead to increases in body weight and lead to increased insulin resistance, a hallmark of type 2 diabetes. The function of insulin is to help shuttle glucose from the blood into tissues, most importantly to skeletal muscle, where one quarter of all glucose in stored. Unsurprisingly, insulin resistance plays a key role in the development of metabolic syndrome, a group of conditions including obesity, altered lipid metabolism, high blood pressure, high blood glucose levels, and systemic inflammation. Although skeletal muscle plays a key role in decreasing blood glucose levels, a direct connection between periodontal bacterial infection and the metabolic function of skeletal muscle has not been established yet. "Metabolic syndrome has become a widespread health problem in the developed world," says first author of the study Kazuki Watanabe. "The goal of our study was to investigate how periodontal bacterial infection might lead to metabolic alterations in skeletal muscle and thus to the development of metabolic syndrome."

Periodontal disease increases risk of major cardiovascular events

2021-03-19 - 2021-03

People with periodontitis are at higher risk of experiencing major cardiovascular events, according to new research from Forsyth Institute and Harvard University scientists and colleagues. In a longitudinal study published recently in the Journal of Periodontology, Dr. Thomas Van Dyke, Senior Member of Staff at Forsyth, Dr. Ahmed Tawakol of Massachusetts General Hospital, and their collaborators showed that inflammation associated with active gum disease was predictive of arterial inflammation, which can cause heart attacks, strokes, and other dangerous manifestations of cardiovascular disease. For the study, researchers performed positron emission tomography and computer tomography (PET and CT) scans on 304 individuals to view and quantify inflammation in the arteries and gums of each patient. In follow-up studies approximately four years later, 13 of those individuals developed major adverse cardiovascular events. Presence of periodontal inflammation was shown to be predictive of cardiovascular events, even after researchers controlled for all other risk factors, such as smoking, high blood pressure, obesity, and diabetes.

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How poor oral hygiene may result in metabolic syndrome

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How poor oral hygiene may result in metabolic syndrome

Periodontal disease increases risk of major cardiovascular events